Neuroprotective effect of Ilex paraguariensis intake on brain myelin of lung adenocarcinoma-bearing male Balb/c mice

MIRANDA AR; REPOSSI G; MIRANDA AR; REPOSSI G; CITTADINI MC; MAZZUDULI GM; CITTADINI MC; MAZZUDULI GM; ALBRECHT C; SORIA EA; ALBRECHT C; SORIA EA

NUTRITION AND CANCER

LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS

Lugar: Londres; Año: 2019 vol. 71 p. 629 - 633

0163-5581

Ilex paraguariensis (IP) is widely consumed as tea with high nutritional value. This plant contains several bioactive phenolic compounds, which are antioxidant and anti-inflammatory. On the other hand, lung adenocarcinoma (LAC) deleteriously involves neoplastic progression, inflammatory paraneoplastic syndromes, and death. Given that brain is a frequent target of this illness, our objective was to determine the neuroprotective effect of IP consumption in LAC-bearing mice. They were orally treated with 50 mg of IP extract/Kg/day (IP50) for 3 weeks. Results (phenolic compounds, lipid peroxides, interleukin 6 -IL-6-, tumor necrosis factor alpha -TNFα-, and luxol-stained myelination) were compared with respect to untreated controls (C) by the T test. IP50 significantly lowed brain IL-6 (2858.12±57.81 pg/g vs. 3801.30±27.34 pg/g), whereas other variables differed in a less extent. C brains showed demyelination (low luxol-staining contrast between gray and white matters), with IP50 increasing myelination (p