INICSA 23916
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
artículos
Título:
4-Locus high-resolution HLA allele and haplotype frequencies in admixed population from Nicaragua
Autor/es:
JEREMY E.STEIN; YONDRA CAROLINA VANEGAS PADILLA; STEVEN G.E.MARSH; JUAN JOSÉ MADRIGAL-SÁNCHEZ; EDEL MARÍA PAREDES; J. ALEJANDRO MADRIGAL; ESTEBAN ARRIETA-BOLAÑOS; MARÍA JOSÉ MOREIRA ESPINOZA; LISBETH SALARZAR-SANCHÉZ ; BRONWEN E. SHAWBG
Revista:
HUMAN IMMUNOLOGY
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2019 p. 1 - 2
ISSN:
0198-8859
Resumen:
A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*04:07:01G, with an estimated frequency of 2.26%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Nicaragua Mestizo" and the identifier AFN3610.
