Molecular mechanisms triggered by bile acids on intestinal Ca2+ absorption

RIVOIRA M; TOLOSA DE TALAMONI N; RODRÍGUEZ V; MARCHIONATTI AM; PEREZ A

CURRENT MEDICINAL CHEMISTRY.

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2018

0929-8673

Bile acids (BAs) are synthesized in the liver and are among the main components of bile. For many years, it was thought that they have only a role as emulsifiers of fat in the small intestine facilitating the absorption of lipids and lipid soluble vitamins. Lately, they are also considered important signaling molecules, not only by regulating their own synthesis, but also having a role in several metabolic diseases. In this review we focus on the effect of deoxycholic, ursodeoxycholic and litocholic acids and their combination upon the intestinal Ca2+ absorption. To make the actions of those BAs clear on this physiological process, an overview of current information about the mechanisms by which the intestinal Ca2+ occurs is described. Finally, detailed statements related to the modulation of redox state, apoptosis and autophagy as molecular mechanisms involved in the action of BAs on intestinal Ca2+ absorption are discussed. Although the mechanisms are still not completely understood, we provide the latest knowledge regarding the effect of BAs on intestinal Ca2+ absorption and discuss the possible therapeutic applications that might evolve as a result.