Sustained Neonatal Inflammation Is Associated with Poor Growth in Infants Born Very Preterm during the First Year of Life

CUESTAS, EDUARDO; RIZZOTTI, ALINA; CERUTTI, MANUEL; AGUILERA, BELÉN

JOURNAL OF PEDIATRICS

MOSBY-ELSEVIER

Año: 2019 vol. 205 p. 91 - 97

0022-3476

Objective: To determine whether a sustained neonatal systemic inflammatory response was associated with poor postnatal growth among infants born very preterm during the first year of life. Study design: We studied prospectively 192 infants born preterm (birth weight ≤1.5 kg and gestational age ≤31 weeks). Weight, length, and head circumference were measured at birth, term, 4, and 12 months of corrected age. Serial C-reactive protein and procalcitonin were measured at 1, 3, 7, 14, and 28 days of age and averaged for each infant. A sustained neonatal systemic inflammatory response was defined as an average C-reactive protein level greater than the median for the group. Analysis was undertaken with linear mixed models. Results: Decreases in mean z scores for weight, length, and head circumference were associated with the presence of a sustained neonatal systemic inflammatory response from birth to 12 months of corrected age (β [95% CI] = ?0.282 [?0.306 to ?0.258]; ?1.899 [?2.028,?1.769]; ?0.806 [?0.910, to ?0.701], P