DIETARY FATTY ACIDS AND OTHER NUTRIENTS IN RELATION TO INFLAMMATION AND PARTICULARY TO ORAL MUCOSA INFLAMMATION. A LITERATURE REVIEW

COSTANTINO E; ACTIS AB

NUTRITION AND CANCER

LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS

Lugar: Londres; Año: 2018 vol. 71 p. 718 - 730

0163-5581

Oral mucosa is site of inflammatory process development.When they are chronic provide a microenvironment based on cytokines and inflammatory mediators that contribute to cancer initiation, progression, invasion and metastasis. Certain dietary fatty acids (FAs) have immunomodulatory, inflammatory and antiinflammatory effects. This review examined the literature on inflammation, mainly referred to the oral mucosa, and its association with dietary FAs and other nutrients. A Pubmed search of studies published in English until June 2018 was carried out.N-3 FAs have shown immunomodulatory and antiinflammatory activity in certain human diseases. These FAs and their mediators may inhibit inflammation, angiogenesis and cancer via multiple mechanisms. Studies on cellular models of murine and human intestinal mucosa indicate association between dietary n-3 FA intake and the inflammatory state of mucosa membranes. Nevertheless scarce information on the association between dietary FAs and oral inflammation could be found. Based on the evidence we hypothesize that n-3 FAs reduce the oral mucosa inflammation thus decreasing the risk of developing precancerous lesions and cancer. Molecular and clinical studies referred to this topic should be carried out as a contribution to the oral cancer prevention.