The Mongolian Gerbil ( Meriones unguiculatus ) as a Model for Inflammationpromoted Prostate Carcinogenesis

TABOGA, SEBASTIÃO R.; MALDONADO, CRISTINA A.; QUINTAR, AMADO A.; MALDONADO, CRISTINA A.; GONÇALVES, BIANCA F.; GONÇALVES, BIANCA F.; QUINTAR, AMADO A.; TABOGA, SEBASTIÃO R.

CELL BIOLOGY INTERNATIONAL

ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD

Año: 2017 vol. 41 p. 1234 - 1238

1065-6995

One of the recognized issues in prostate cancer research is the lack of animal models allowing the research of pathological, biochemical, and genetic factors in immunocompetent animals. Our research group has successfully employed the gerbil in several studisfor prostate diseases. In the present work, we aimed to analyze the effect of chronic bacterial inflammation on MNU-induced prostate carcinogenesis in gerbils Histopathological assessment of the prostatic complex revealed that treatment combinations with MNU plus testosterone or bacterial infection resulted in a promotion of prostate cancer, with bacterial inflammation being more effective in increasing premalignant and malignant tissular alterations than testosterone in the prostate. Furthermore, chronic bacterial inflammation itself induced premalignant lesions in the ventral lobe and increased their frequency in the dorsolateral lobe as well as malignant lesions in the ventral prostate. These animals showed a rich inflammatory microenvironment, characterized as intraluminal and periductal foci. These data indicate that chronic inflammation induced by E. coli acts as a potent tumor promoter, in the early stages of carcinogenesis in the gerbil, in line with the hypothesis of inflammation supporting several steps of tumor development in the prostate gland.