Differential tissue distribution ofTrypanosoma cruzi during acute experimental infection: further evidence using natural isolates

LO PRESTI SILVINA; PAGLINI PATRICIA; RIVAROLA WALTER; BÁEZ ALEJANDRA; BAZÁN CAROLINA; MOYA DIEGO; VELÁZQUEZ DANIELA; STRAUSS MARIANA

MOLECULAR AND BIOCHEMICAL PARASITOLOGY

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2018

0166-6851

In the present work, we evaluated the effect of mixed Trypanosoma cruzi infections, studying the biological distribution of the different parasites in blood, heart and skeletal muscle during the acute phase. Albino Swiss mice were infected with different parasite strain/isolates or with a combination of them. The parasites in the different tissues were typified through specific PCR, population variability was analyzed through RFLP studies and parasitological and histopathological parameters were evaluated. We found a predominance of TcII and TcVI in all tissues samples respect to TcV and different parasite populations were found in circulation and in the tissues from the same host. These results verify the distribution of parasites in host tissues from early stages of infection and show biological interactions among different genotypes and populations of T. cruzi.