Antitumoral, Antihypertensive, Antimicrobial, and Antioxidant Effects of an Octanuclear Copper(II)-Telmisartan Complex with an Hydrophobic Nanometer Hole

M. S. ISLAS; J. J. MARTÍNEZ MEDINA; L. L. LOÌPEZ TEÌVEZ; T. ROJO; L. LEZAMA; M. GRIERA MERINO; L. CALLEROS; M. A. CORTES; M. RODRIGUEZ PUYOL; G. A. ECHEVERRÍA; O. E. PIRO; E. G. FERRER; P. A. M. WILLIAMS

Chascomús (BA)

Congreso; IV Latin American Meeting on Biological Inorganic Chemistry-V WOQUIBIO; 2014

WOQUIBIO

The octapeptide Angiotensin II (AII) is a physiologically active major substance of the renin-angiotensin system (RAS) that causes muscles to contract, producing hypertension. Sartans are drugs of design that inhibit the RAS AT1 receptor blockers (ARBs) then inhibiting the vasoconstrictor effects of AII.1 Telmisartan displayed a highly selective and potent antagonism of the AT1 receptor in many tissues. Copper is an essential element for cellular respiration, iron homeostasis, pigment formation, neurotransmitter production, connective tissue biosynthesis, and antioxidant defense. It is interesting to note that the complexation of ARBs with some transition metals could be a useful strategy to develop novel antihypertensive drugs with enhanced biological properties. In this communication we report the synthesis and structural characterization of a new coordination complex of copper(II) and telmisartan, its antihypertensive, cytotoxic, antibacterial and antifungal effects.