IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
Phototoxic effects of Heterophyllaea pustulata (Rubiaceae)
Autor/es:
NUÑEZ MONTOYA, S.C.; COMINI, L.R.; RUMIE VITTAR, B.; FERNANDEZ, I.; RIVAROLA, V.; CABRERA, J.L.
Revista:
TOXICON
Editorial:
Elsevier
Referencias:
Año: 2008 vol. 51 p. 1409 - 1415
ISSN:
0041-0101
Resumen:
Abstract: Heterophyllaea pustulata (Rubiaceae), a South American genus, is a phototoxic shrub that grows in the Andean mountain range of the Northwest of Argentina, popularly known as cegadera. Animals that ingest the aerial parts of this plant suffer a typical primary photosensitization reaction, clinically revealed by dermatitis and blindness in severe cases. Anthraquinone derivatives (AQs), the main metabolites of this species, are characterized as Type I and/or Type II photosensitizers according to their physicochemical properties. The natural toxicity conditions were reproduced in vivo assays by oral administration of soranjidiol and rubiadin, the main components of the aerial parts. By HPLC analysis, these AQs were determined in serum and quantified in the skin of experimental animals.
