INVESTIGADORES
QUIROGA Cecilia
artículos
Título:
Using genomic data to determine the diversity and distribution of target site motifs recognized by class C-attC group II introns.
Autor/es:
CECILIA QUIROGA; DANIELA CENTRÓN
Revista:
JOURNAL OF MOLECULAR EVOLUTION
Editorial:
SPRINGER
Referencias:
Año: 2009 vol. 68 p. 539 - 549
ISSN:
0022-2844
Resumen:
The attC sites are well-known integrase-targeted
elements involved in the insertion and excision of
gene cassettes from integrons. Recently, functional analysis
of Sma.I2, a class C-attC group II intron, showed that this
mobile element invades the attC sites through a specific
process. The analysis of genomic data indicates that class CattC
group II introns are independently acquired by their
bacterial hosts and evolve in the recognition of a variety of
target sites, including the attCs. In addition, adaptation of
class C-attC group II introns seemed to be favourable for
particular genera, such as Shewanella, suggesting a possible
niche for the spread of class C-attC group II introns inserted
at attC sites. This understanding suggests a functional role
of short palindromic DNA sequences, such as the attCs, as
important tools for the acquisition of mobile elements
associated with horizontal gene transfer.
