INVESTIGADORES
PEREZ Claudio javier
congresos y reuniones científicas
Título:
Riboflavin-UVa gelatin crosslinking: Design of a biocompatible thermoresponsive enhanced biomaterial for tissue engineering
Autor/es:
J.M.GALDOPORPORA; M.F. MORCILLO; C. J. PÉREZ; M.V. TUTTOLOMONDO; M. DESIMONE
Lugar:
Mar del Plata
Reunión:
Simposio; XVI Simposio Latinoamericano de Polimeros; 2018
Institución organizadora:
Division Polimeros-INTEMA
Resumen:
INTRODUCTIONThe development of biomaterials and hydrogels has attracted great attention for wound healing, drug delivery and medical purposes. A protein was selected to provide proper support to these particles. Gelatin is a hydrophilic protein obtained by partial hydrolysis ofcollagen, the main fibrous protein constituent in bones, cartilages and skins. Therefore, the source, age of the animal and type of collagen are all intrinsic factors influencing the properties of gelatins1. Riboflavin (Vitamin B2) acts as a photosensitizer producing oxygen free radicals, which induce physical cross linking of collagen.We investigate the rigidity enhancement in gelatin based on the effect of the treatment seen in collagen hydrogels. In addition, the use of gelatin in nanobiotechnology is ubiquitous as a cellencapsulation, drug-delivery and nanoparticle platform material2.