Chemical components and antiulcerogenic activity of Baccharis polifolia Griseb.

PERALTA CECILIA MARIANA; GARCÍA EDUARDO; NIETO MATÍAS; GIANELLO JUAN CARLOS; MARÍA ALEJANDRA; PELZER LILIAN

Buenos Aires

Congreso; VII Jornadas Multidisciplinarias de la Sociedad Argentina de Biología; 2005

The interest in the phytochemical study of the species belonging to the genus Baccharis derives from the fact that several of them, particularly those widely used in popular medicine, have been reported to have significant pharmacological and therapeutics properties. Baccharis polifolia Griseb, placed in the Cuyo region, have been used in folk medicine for gastrointestinal disorders. The aim of this study was to identify and characterize secondary metabolites present in B. polifolia. The methodology employed was the usual one in chemical-pharmacologycal investigations of natural product studies. From the chromatographic resolution of the ethanolic soluble fraction of the methanol extract, previously defatted with hexane, were isolated nevadensina, gardenina B, xanthomicrol and 7-methylsudachitine. Identification was performed by uni-and bidimensional spectroscopic techniques 1H-NMR and 13C-NMR and GC-ME combined techniques. The antiulcerogenic activity of B. polifolia was assessed in according to the method of Robert et al. absolute ethanol administered orally was employed as necrotizing agent in Wistar rats. The degree of erosion was assessed from a scoring from 0 to 5 (maximal damage control). Previously we have demonstrated the B. polifolia ethanolic extract prevents the formation of gastric lesions (p<0.001 vs. damage control). In this experiment, gardenina B and xanthomicrol decreased the ulceration size (p<0.01 vs. control). The higher activity of the ethanolic extract of B. polifolia can be accounted for the support the use in traditional medicine of Baccharis polifolia to treat digestive disorders.