Improvement in Poly(e-caprolactone) bio-activity. Structural characterization and invitro assessment

MARIO D. NINAGO; ANDRÉS E. CIOLINO; MARCELO A. VILLAR

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS

TAYLOR & FRANCIS AS

Lugar: Londres; Año: 2020 vol. 69 p. 201 - 2010

0091-4037

Model PCL homopolymers (anionic polymerization) were synthetized and chemicallyfunctionalized with anhydrides to improve their bio-activity. Modified polyesters were used to fabricate highly porous PCL membranes by leaching technique, reaching porosities values up to 86.1 %. Microstructural characterization revealed that chemical modification did not affect thermal properties and mechanical stabilities of PCL membranes. Invitro assays were carried out by soaking samples in simulated body fluid (SBF) solution. By SEM-EDX and TGA analyses, it was observed that modified polyesters exhibited a hydroxyapatite layer over polymeric surfaces, with calcium/phosphorous ratio of 1.58, close to the value reported by literature for hard tissue.