Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks

MARÍA SOLEDAD GASTÓN; MARIANA P. CID; ANA MARIA VAZQUEZ; MARIA F. DECARLINI; GABRIELA DEMMEL; LAURA ROSSI; MARIO LEANDRO AIMAR; NANCY A. SALVATIERRA

PHARMACEUTICAL BIOLOGY

TAYLOR & FRANCIS INC

Lugar: 2016 Feb 25:1-8. [Epub ahead of print]; Año: 2016 vol. 54 p. 1954 - 1961

1388-0209

Abstract: Background: Coriandrum sativum (coriander) is an herb grown throughout the world as a culinary, medicinal or as essential oil crop. In Iranian and other traditional medicines it is used for relief of anxiety and insomnia. The hydro-alcoholic and aqueous extract of coriander aerial parts and seeds, systemically administered, had anxiolytic and sedative action in rodents, but little is known about their central effect. Purpose: we investigated the effects of coriander essential oil from seeds and its major component linalool, intracerebroventricularly administered, on different behavioral parameters in an Open Field test of neonatal chicks. Materials and methods: A gas chromatograph-mass and gas chromatograph-flame ionization detector were employed to determinate the chemical composition of coriander essential oil. Intracerebroventricularly administration of saline (control), sedative diazepam dose (standard drug), coriander essential oil and linalool were carried out to evaluate the pharmacological and behavioral effects in an Open Field test. Results: Coriander oil and linalool (8.6 and 86 μg) decreased the squares crossed number, attempt to escapes, the number of defecations and distress calls respect to saline group and were similar to sedative diazepam dose. In addition, both doses tested significantly increased the time spent in sleeping posture and were comparable with data obtained for sedative diazepam dose. Conclusion: The essential oil of Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 μg doses intracerebroventricularly administered in neonatal chicks. Pharmacological and behavioral responses of coriander essential oil may be due to the presence of monoterpene linalool, major constituent, which also induced a similar sedative effect in neonatal chicks. Therefore, both could be useful in clinical therapy similar to diazepam.