INVESTIGADORES
MENZELLA Hugo Gabriel
artículos
Título:
Recombinant approaches to large polyketide molecules as potential drugs
Autor/es:
PEIRU S.; GRAMAJO H.; MENZELLA H.G. (CORRESPONDING)
Revista:
Drug Discovery Today: Technologies
Editorial:
ELSEVIER ACADEMIC PRESS INC
Referencias:
Lugar: Amsterdam; Año: 2010 vol. 7 p. 105 - 113
ISSN:
1740-6749
Resumen:
Combinatorial biosynthesis of polyketide synthases through genetic engineering
should provide complex compounds as drug development candidates. Different strategies
are currently being evaluated to create libraries of new compounds. The number
of different compounds in such libraries and the quantities that can be made
using combinatorial strategies will determine the impact of this technology on
the pharmaceutical industry.
