Copper Handling in the Salmonella Cell Envelope and Its Impact on Virulence

CHECA, SUSANA K.; GIRI, GERMÁN F.; ESPARIZ, MARTÍN; ARGÜELLO, JOSÉ M.; SONCINI, FERNANDO C.

TRENDS IN MICROBIOLOGY

ELSEVIER SCIENCE LONDON

Año: 2021

0966-842X

Copper (Cu) plays a key role at the host?pathogen interface as both an essential element and a toxic element. Intracellular strains of pathogenic Salmonella have acquired the periplasmic Cu chaperone, CueP, and the thiol oxidoreductases complex Scs, while losing the ancestral Cu-detoxification Cus system. Coregulation of these species-specific factors link Cu with redox stress and allows Salmonella to counteract Cu toxicity during infection.