INVESTIGADORES
RUYBAL Paula
artículos
Título:
Mycobacterium bovis BCG as a delivery system for the RAP-1 antigen
Autor/es:
M.P. SANTANGELO; D. MCINTOSH; F. BIGI; G.R.G. ARMOA; A.S.D. CAMPOS; P. RUYBAL; O.A. DELLAGOSTIN; J. MCFADDEN; T. MENDUM; B. GICQUELE,; N. WINTER; M. FARBER; A. CATALDI
Revista:
VACCINE
Editorial:
Elsevier
Referencias:
Año: 2007 vol. 25 p. 1104 - 1113
ISSN:
0264-410X
Resumen:
Babesia bovis is the causative agent of babesiosis, a tick-borne disease that is a major cause of loss to livestock production in Latin America.
Vaccination against Babesia species represents a major challenge against cattle morbidity and mortality in enzootic areas. The aim of this
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
Vaccination against Babesia species represents a major challenge against cattle morbidity and mortality in enzootic areas. The aim of this
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
Vaccination against Babesia species represents a major challenge against cattle morbidity and mortality in enzootic areas. The aim of this
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
Vaccination against Babesia species represents a major challenge against cattle morbidity and mortality in enzootic areas. The aim of this
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
is the causative agent of babesiosis, a tick-borne disease that is a major cause of loss to livestock production in Latin America.
Vaccination against Babesia species represents a major challenge against cattle morbidity and mortality in enzootic areas. The aim of this
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovis
Babesia species represents a major challenge against cattle morbidity and mortality in enzootic areas. The aim of this
study was to evaluate the capacity of Bacille Calmette-Guerin (BCG) to deliver the rhoptry associated protein (RAP-1) antigen of B. bovisB. bovis
and to stimulate specific cellular and humoral immune responses in mice. Two of five mycobacterial expression vectors efficiently expressed
the antigen. These constructs were subsequently studied in vivo following three immunization protocols. The construct with the greatest in
vivo stability proved to be the one that induced the strongest immune responses. Our data support the hypothesis that specific T lymphocyte
priming by rBCG can be employed as a component of a combined vaccine strategy to induce long-lasting humoral and cellular immune
responsiveness towards B. bovis and encourage further work on the application of rBCG to the development of Babesia vaccines.
© 2006 Elsevier Ltd. All rights reserved.
© 2006 Elsevier Ltd. All rights reserved.
© 2006 Elsevier Ltd. All rights reserved.
© 2006 Elsevier Ltd. All rights reserved.
B. bovis and encourage further work on the application of rBCG to the development of Babesia vaccines.
© 2006 Elsevier Ltd. All rights reserved.