INVESTIGADORES
MARDER Nora Mariel
artículos
Título:
Neuroactive flavonoid glycosides from Tilia petiolaris DC. extracts
Autor/es:
L. M. LOSCALZO; C. WASOWSKI; M. MARDER
Revista:
PHYTOTHERAPY RESEARCH
Editorial:
Wiley
Referencias:
Año: 2009 vol. 23 p. 1453 - 1459
ISSN:
0951-418X
Resumen:
Pharmacological assay guided purification of an ethanol extract of Tilia petiolaris DC. inflorescences resulted
in the isolation and identification of isoquercitrin (ISO), quercetin 3-O-glucoside-7-O-rhamnoside (QUE) and
kaempferol 3-O-glucoside-7-O-rhamnoside (KAE). The behavioral actions of these glycosylated flavonoids
were examined in the hole board, locomotor activity and thiopental-induced loss of righting reflex tests in
mice. QUE (10 and 30 mg/kg) and KAE (30 mg/kg), intraperitoneally (i.p.) administered to mice, reduced all
the parameters measured in the hole board test, but ISO (30 mg/kg) only reduced the number of rearings.
Meanwhile QUE at 30 mg/kg i.p. also decreased the ambulatory locomotor activity and increased the sodium
thiopental-induced time of loss of the righting reflex suggesting a clear depressant action.
The above results demonstrate the occurrence of neuroactive flavonoid glycosides in Tilia.
in the isolation and identification of isoquercitrin (ISO), quercetin 3-O-glucoside-7-O-rhamnoside (QUE) and
kaempferol 3-O-glucoside-7-O-rhamnoside (KAE). The behavioral actions of these glycosylated flavonoids
were examined in the hole board, locomotor activity and thiopental-induced loss of righting reflex tests in
mice. QUE (10 and 30 mg/kg) and KAE (30 mg/kg), intraperitoneally (i.p.) administered to mice, reduced all
the parameters measured in the hole board test, but ISO (30 mg/kg) only reduced the number of rearings.
Meanwhile QUE at 30 mg/kg i.p. also decreased the ambulatory locomotor activity and increased the sodium
thiopental-induced time of loss of the righting reflex suggesting a clear depressant action.
The above results demonstrate the occurrence of neuroactive flavonoid glycosides in Tilia.
Tilia petiolaris DC. inflorescences resulted
in the isolation and identification of isoquercitrin (ISO), quercetin 3-O-glucoside-7-O-rhamnoside (QUE) and
kaempferol 3-O-glucoside-7-O-rhamnoside (KAE). The behavioral actions of these glycosylated flavonoids
were examined in the hole board, locomotor activity and thiopental-induced loss of righting reflex tests in
mice. QUE (10 and 30 mg/kg) and KAE (30 mg/kg), intraperitoneally (i.p.) administered to mice, reduced all
the parameters measured in the hole board test, but ISO (30 mg/kg) only reduced the number of rearings.
Meanwhile QUE at 30 mg/kg i.p. also decreased the ambulatory locomotor activity and increased the sodium
thiopental-induced time of loss of the righting reflex suggesting a clear depressant action.
The above results demonstrate the occurrence of neuroactive flavonoid glycosides in Tilia.Tilia.