INVESTIGADORES
MARDER Nora Mariel
artículos
Título:
Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor
Autor/es:
M. MARDER; J. ZINCZUK; M. I. COLOMBO; C. WASOWSKI; H. VIOLA; C. WOLFMAN; J. H. MEDINA; E. A. RÚVEDA; A. C. PALADINI
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Referencias:
Año: 1997 vol. 7 p. 2003 - 2008
ISSN:
0960-894X
Resumen:
A series of haiogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already described, indicates that substitutions at position 6 or 6 and 3' in the flavone nucleus are the only ones that give rise to high affinity BDZR ligands.
