INVESTIGADORES
MARDER Nora Mariel
artículos
Título:
6-Bromo-3'-nitroflavone, a new high affinity benzodiazepine receptor agonist, recognizes two populations of cerebral cortical binding sites.
Autor/es:
H. VIOLA; M. MARDER; C. WOLFMAN; C. WASOWSKI; J. H. MEDINA; A. C. PALADINI
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Referencias:
Año: 1997 vol. 7 p. 373 - 378
ISSN:
0960-894X
Resumen:
The synthesis and biochemical characterization of 6-bromo-3-nitroflavone (1) is presented. Compound 1 has higher affinity for cerebellar and cerebral cortical than for striatal, hippocampal, or spinal cord benzodiazepine receptors (BDZ-Rs). In the cerebral cortex it recognizes two populations of binding sites (Kis 1.2 nM and 15.5 nM, respectively), and at doses of 0.01 to 0.3 mg/kg, ip produces anxiolytic effects in mice.
