Effects of hydroxy-xanthones on dipalmitoylphosphatidylcholine lipid bilayers: A theoretical and experimental study

MB SIERRA; ALARCÓN, L.M ; D.GERBINO; VI PEDRONI; BUFFO, F.E.; MAMORINI

CHEMISTRY AND PHYSICS OF LIPIDS

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2017

0009-3084

Xanthones and derivatives are natural active compounds whose interest has been increased due to itsseveral pharmacological effects. In this work, effects of hydroxy-xanthones on the physicochemicalproperties of dipalmitoylphosphatidylcholine (DPPC) liposomes have been investigated in terms of lipidbilayerfluidity, by means of molecular dynamics simulations and temperature dependence of zetapotential studies. Experimental results predict, in good agreement with simulations, that xanthones areable to be incorporated into DPPC liposomes with certain localization,fluidizing the bilayer. Both effects,localization andfluidity were found to be dependent of the number of hydroxilic substituents of thexanthone and the lipid phase state.