Lipidic nanoparticules: a model function to predict the transition temperature of DPPC-DMPC mixtures

BUFFO, F.E.; M.B.SIERRA; VI PEDRONI; MAMORINI

Advanced Materials Science

oatexts

Año: 2017

2398-6883

temperature dependence of the Zeta Potential (ZP). This technique presents high sensitivity and small amount of sample required, that is, 70% less than that requiredin the use of conventional calorimeters. A model function is proposed to adjust the thermotropic behavior of the DPPC-DMPC system. From the adjustment,temperature transition (Ttransition) data as a function of the composition are obtained. The objective of this paper is to propose, from those few Ttransition-compositiondata, a function that allows obtaining Ttransition for any composition of the mentioned system. Moreover, graph of phase boundaries for these mixed-lipid vesicles wasconstructed by plotting the delimiting temperatures of the main phase transition as a function of the lipid composition of the vesicle. The combination of the zetapotential technique and the mathematical processing of their data would be a simple and useful tool for determining the transition temperatures of more complexmixtures.