CD13 expression and interaction with its binding-partner galectin 1 in liver tumor and sinusoidal endothelial cells

SARRIAS, LUCIANA; ESPELT, MARÍA V.; RABINOVICH, GABRIEL A.; ELOLA, MARÍA TERESA; TRONCOSO, MARÍA F.

BUENOS AIRES

Congreso; REUNION ANUAL BIOCIENCIAS 2020. LXV REUNION ANUAL DE SAIC; 2020

SOCIEDAD ARGENTINA DE INVESTIGACION CLINICA

CD13/aminopeptidase N is a glycosylated membrane exopeptidase, which expression is increased in endothelial cells during tumor-related angiogenesis. The β-galactoside-binding protein galectin-1 (Gal1) is up-regulated in hepatocellular carcinoma (HCC), the most common type of liver cancer. Previously, we found that hepatocyte-derived Gal1 promotes liver sinusoidal endothelial cell (LSEC) proliferation and migration, suggesting Gal1 contribution to angiogenesis in liver tumors. Recently, using a proteomic approach, we identified CD13 as a novel ligand for Gal1 in human SK-HEP-1 LSECs. Here, we analyzed CD13 expression in a wide set of human cancer tissues using Oncomine and The Cancer Genome Atlas (TCGA) databases, and in liver tumor samples through UALCAN platform. CD13 expression was decreased in HCC samples (n=371) compared with normal tissues (n=50) (p