MECHANISMS UNDERLYING THE ANTI-TUMORAL EFFECTS OF THE FLAVONOID 2’-NITROFLAVONE IN HUMAN TRIPLE-NEGATIVE BREAST CANCER CELLS

VACHETTA, VANINA S.; BLANK, VIVIANA; BUSTOS, MILAGROS; MARDER, MARIEL; ORTEGA, MARÍA GABRIELA; PAULINO ZUNINI, MARGOT; ELOLA, MARÍA TERESA; TRONCOSO, MARÍA F.

MAR DEL PLATA

Congreso; Reunión anual de SOCIEDADES DE BIOCIENCIAS SAIC-SAI-SAFIS | 2022; 2022

SOCIEDAD ARGENTINA DE INVESTIGACION CLINICA

Triple-negative breast cancer (TNBC) is one the most aggressive subtypes of mammary tumors. Flavonoids are polyphenolic compounds that cause several antineoplastic effects. We previously described that the synthetic flavonoid 2’-nitroflavone (2’NF) inhibits viability, survival and migration of human TNBC cells. Herein, our aim pointed to find out mechanisms that mediate 2’NF anti-tumoral effects in these cells. We first evaluated MDA-MB-231 cell cycle progression (propidium iodide staining, flow cytometry) upon treatment. 2’NF (5 M, 72 h) decreased the percentage of cells in G1 phase from 59.30±1.63 (control) to 43.00±.2.29% (p