Disruption of skin homeostasis activates a lectin-driven circuitry that controls immunopathology at the cross-roads of cancer and inflammatory psoriatic disease

PINTO N; LAPORTE N; ABBA MC; MORALES RM; GATTO SG; PÉREZ SÁEZ JM; BACIGALUPO ML; TRONCOSO MF; SUNDBLAD V; RABINOVICH GA; CERLIANI JP

Congreso; Reunión de Sociedades de Biociencias; 2020

Disruption of skin homeostasis by environmental insultseventually activates pathologic circuitries leading to inflammationand carcinogenesis. Here we report essentialroles of Galectin-7 (Gal-7), a b-galactoside-binding proteinpreferentially expressed in keratinocytes (KCs), in skincarcinogenesis and inflammatory disorders. In a chemicallyinduced carcinogenesis model, mice constitutivelyover-expressing Gal-7 in KCs (Tg46 mice) showed highernumber (p