Improvement of antibacterial activity the Cu(II)Chrysin complex by the addition of the secondary ligand 1,10-phenanthroline against clinical isolates of Escherichia coli and methicillin-resistant Staphylococcus aureus

LUCIANA J. BOGADO; LORENA E. GUEVARA; LIBERTAD L. LÓPEZ TÉVEZ; JUAN J. MARTÍNEZ MEDINA

Rosario

Congreso; 7ma Reunión Internacional de Ciencias Farmacéuticas; 2023

Universidad Nacional de Córdoba y Universidad Nacional de Rosario

We previously studied the antimicrobial activity and safety profile of Chrys and its binary complex (CuChrys). The aim of this work was to evaluate the antibacterial activity of the ternary copper complex with Chrys and Phen (CuChrysPhen) against strains derived from the American Type Culture Collections (ATCC) and strains from clinical isolates. The results showed that the CuChrysPhen complex has antibacterial activity relevant from a clinical perspective against both ATCC strains (except for P. aeruginosa and K. pneumoniae) and clinical isolates. Clinical isolates are more resistant than ATCC strains probably due to their resistance profiles. The highest MIC value matches with the highest resistant strain E. coli 1763, which is resistant to ampicillin, ciprofloxacin, ampicillin sulbactam, and trimethroprim sulfamethoxazole. MIC values are relevant for S. aureus 5627 due to is resistant to methicillin, whereas S. aureus 5646 is resistant to methicillin, erythromycin, clindamycin, levofloxacin and gentamicin. On the contrary, the binary CuChrys complex showed no antibacterial activity. The addition of the secondary ligand Phen improved the antibacterial activity of CuChrys. In summary, coordination compounds could be alternative antibacterial agents in the resistance era.