Antibacterial activity and safety evaluation of ternary Sulfadiazine Co(II) and Zn(II) complexes including 2,2'-bipyridine as a secondary ligand

JUAN J. MARTÍNEZ MEDINA; JAVIER L. RODRÍGUEZ; CRISTIAN VILLA-PÉREZ; DELIA B. SORIA

Rosario

Congreso; 7ma Reunión Internacional de Ciencias Farmacéuticas; 2023

Universidad Nacional de Córdoba y Universidad Nacional de Rosario

We previously reported the antimicrobial activity of the Co(SDZ)2bpy and Zn(SDZ)2bpy complexes against Gram(-) and Gram(+) bacterial strains derived from the American Type Culture Collections (ATCC). This work aimed to further evaluate these complexes´ antimicrobial properties against other ATCC strains and clinical isolates of Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA). Besides, the safety evaluation of these complexes at two experimental levels was assessed. The results showed that the ligand SDZ has antimicrobial activity relevant from a clinical perspective against both ATCC strains and against the MRSA strains (S. aureus 5627 and S. aureus 5646). The complexes showed relevant antimicrobial activity against these strains (except S. aureus 5646). The Co(SDZ)2bpy and Zn(SDZ)2bpy complexes retain the antimicrobial activity against one MRSA strain (S. aureus 5627). The complexes induce neither mutagenicity nor acute toxicity on A. salina nauplii until 600 µg mL-1. This concentration is higher than that required for antimicrobial action. In summary, complexation is a useful strategy for designing novel and safe antimicrobial agents.