INVESTIGADORES
MARTÍNEZ MEDINA juan JosÉ
congresos y reuniones científicas
Título:
Improved antibacterial activity of Magnesium(II)Silybin complex against clinical isolates of Escherichia coli and methicillin-resistant Staphylococcus aureus
Autor/es:
JAVIER L. RODRÍGUEZ; JUAN J. MARTÍNEZ MEDINA; LUCIANA G. NASO
Lugar:
Rosario
Reunión:
Congreso; 7ma Reunión Internacional de Ciencias Farmacéuticas; 2023
Institución organizadora:
Universidad Nacional de Córdoba y Universidad Nacional de Rosario
Resumen:
On the basis that metal-chelated flavonoids show better biological effects than flavonoids, we have synthesized and characterized the coordination compound of silybin with magnesium(II) cation, named MgSil. Here we report the structural optimization and the assessment of the antimicrobial activity of MgSil against ATCC strains and clinical isolates. The structure of the new compound -[Mg(Silybin)(H2O)2]Cl.3H2O- proposed attending experimental measurements was validated by computational methods (optimizations in gas phase at B3LYP/6-311++G** theory level). MgCl2 showed no antimicrobial action, whereas silybin and Mgsil showed antibacterial activity. Complexation improved the activity of silybin against E. coli ATCC 25922 and S. aureus ATCC 29213 (maintaining the activity against the other ATCC strains). Then, we determined the antibacterial activity of MgSil on clinical isolates of E. coli and methicillin-resistant S. aureus. Silybin showed MIC values without clinical relevance against these isolates, whereas MgSil showed relevant MIC values against the clinical isolates of E. coli and S. aureus. In summary, complexation is a useful strategy for designing novel and safe therapeutic agents with enhanced antimicrobial activity.
