INVESTIGADORES
LUCINI Maria magdalena
artículos
Título:
Gaining acceptability for the Bayesian decision theoretic approach in dose-escalation studies
Autor/es:
ZHOU, YINGHUI; LUCINI, MAR√ćA MAGDALENA
Revista:
PHARMACEUTICAL STATISTICS
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2005 vol. 4 p. 161 - 171
ISSN:
1539-1604
Resumen:
There has recently been increasing demand for better designs to conduct first-into-man dose-escalation studies more efficiently, more accurately and more quickly. The authors look into the Bayesian decision-theoretic approach and use simulation as a tool to investigate the impact of compromises with conventional practice that might make the procedures more acceptable for implementation