Oxitocin and Prostaglandins F2a and E2 do not enhance HIV antigen production in vitro.

A.CEBALLOS, R.D. RABINOVICH, S.MARQUINA, P.N.FERNÁNDEZ LARROSA, L.MARTINEZ PERALTA.

ARCHIVES OF VIROLOGY

Springer Verlag

Lugar: Viena, Austria.; Año: 2003 vol. 148 p. 531 - 535

0304-8608

Oxytocin and prostaglandins are hormones involve in labour and are used clinically for its induction. The purpose of this study was to measure the effect of oxytocin, PGF2a, and PGE2 on the HIV-1 replication in vitro. Acutely and persistently infected cells were treated with different oxytocin, PGF2a and PGE2 concentrations. Supernatants were removed at different times post treatment and p24 production was determined. No significant effect was found using the different concentrations of oxytocin or prostaglandins on p24 antigen production in acutely or persistently infected cells, except for PGF2a 1ìM in persistently infected cells. These results showed that oxytocin and prostaglandins could be used clinically for labor induction without any direct enhanced viral production. Besides, the results with PGF2a in the highest concentrations studied may indicate a pharmacological effect, and this may have a potential use like antiretroviral. Keywords: mother to child transmission; oxytocin; prostaglandin; HIV-1