Assesment of the pharmacological interaction between loperamide and endectocide compounds

LIFSCHITZ, A.; VIRKEL, G.; SALLOVITZ, J.; IMPERIALE, F.; LANUSSE, C

Congreso; 18th.International Conference of the World Association for the Advancement of Veterinary Parasitology; 2001

Moxidectin (MXD) is a milbemycin endectocide compound active at extremely low dosages against a wide variety of nematode and arthropod parasites. Different pharmacological approaches are currently being tested to delay the bile-faecal elimination and to obtain increased systemic availability for endectocide molecules in ruminants. Loperamide (LPM) is an opioid derivative, whose main pharmacological action is to abolish intestinal propulsive peristaltic waves. The influece of LPM on the kinetics of MXD was evaluated. The drug-drug interaction of LPM with the P-glycoprotein delay MXD elimination and may increase its antiparasitic efficacy