Electromagnetic SAR Determination for Fe3O4 Nanoflowers Loaded in Melanoma Tumor and Comparison with Disipation in Agarose Ferrogel

ACTIS DG; BRUVERA I J; SOTO P; ROGUIN, L. P; BLANK VC; FERNANDEZ VAN RAAP; MENDOZA ZELIS P

Conferencia; 2021 Around-the-Clock Around-the-Globe Magnetics Conference; 2021

Radiofrequency magnetic cycles of ex vivo melanoma tumor tissue loaded with Fe3O4 nanoflowers(NF) were measured for several field conditions and compared with the cycles of a ferrogel (FG)obtained incorporating the NF in agarose gel. Such cycles were obtained via an ac electromagnetictechnique[1]?[3]. Results were studied in order to understand usually reported SAR values differences between the actual application environment (tumor) and a typical characterization model (FG)for magnetic hyperthermia[4]?[6]. The linearity of the response, coercive field and SAR values wereanalyzed. Additionally, a novel method for the determination of the NF mean relaxation time fromthe cycles is presented. Results show a systematic difference in magnetic response at therapeuticfield setting (98 kHz, 17.4 kA/m) between the NF incorporated in tumors and those in the FG.REFERENCES[1] S. Gudoshnikov et al., Journal of Superconductivity and Novel Magnetism, vol. 26, pp. 857-860, 2013.[2] E. Garaio et al., Journal of Magnetism and Magnetic Materials, vol. 368, pp. 432-437, 2014.[3] I. J. Bruvera et al., Journal of Magnetism and Magnetic Materials, vol. 491, pp. 165563, 2019.[4] B. Lahiri et al., Journal of Magnetism and Magnetic Materials, vol. 441, pp. 310?327, 2017.[5] D. F. Coral et al., Langmuir, vol. 32, pp. 1201?1213, 2016.[6] A. Rousseau et al., Journal of Magnetism and Magnetic Materials, vol. 518, pp. 167403, 2021.