INVESTIGADORES
ROGUIN leonor Patricia
congresos y reuniones científicas
Título:
Antiangiogenic effect of a penicillin derivative in melanoma
Autor/es:
BARRIONUEVO E; CORNIER P.G.; DELPICCOLO CM; MATA E.G.; ROGUIN LP; BLANK VC
Lugar:
Buenos Aires
Reunión:
Congreso; Reunión Anual de Sociedades de Biociencia. SAIC. SAI. SAFIS.; 2020
Institución organizadora:
SAIC, SAI, SAFIS
Resumen:
In a previous study, we demonstrated that TAP7f, a compound formed by penicillin linked to the dipeptide Leu-Phe through a triazole group, inhibited melanoma metastasis by the downregulation of β-catenin and integrin αVβ3. Since these molecules may be involved in the promotion of melanoma angiogenesis, we further explored the antiangiogenic effect of TAP7f. In this sense, we found that in HMEC-1 human endothelial cells, TAP7f inhibited cell proliferation (IC50 23±4 µM, 72h) and also cell migration by 36±8% (5 µM, p
