Photophysics and photobiology of different liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2dimethylamino)ethylsulfanyl]phthalocyaninato-zinc(II)

LÓPEZ ZEBALLOS N; MARINO V.J.; GARCIA VIOR M.C.; CHIARANTE N.A; ROGUIN, L. P; AWRUCH J; DICELIO L.E.

DYES AND PIGMENTS

ELSEVIER SCI LTD

Lugar: Liverpool; Año: 2013 vol. 96 p. 626 - 635

0143-7208

Six different liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (Pc9) were investigated to establish how the environments affect their photophysical and photobiological properties. Size, incorporation efficiency, and solubility during a time period were evaluated. All Pc9-liposomal formulations were efficient singlet oxygen quantum yield generators. The photobiological potentials (photobiological potencies) were evaluated on human nasopharynx KB carcinoma cells. None of the formulations studied showed cytotoxic effects in the absence of light, whereas all of them showed good performance after irradiation. The 50% inhibition of cell proliferation (IC50) was in the range of 0.21-0.47 M for S-PEG and D1, respectively. A lysosomal localization was found for S-PEG as well as for S.