Antiproliferative activity of various flavonoids and related compounds. Additive effect of interferon-a2b

V.C. BLANK; C. POLI; M. MARDER; L.P. ROGUIN

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Elsevier

Lugar: The Netherlands; Año: 2004 vol. 14 p. 133 - 136

0960-894X

The antiproliferative activity of several natural flavonoids and a series of synthetic derivatives was evaluated in vitro against a cell line derived from a human cervical carcinoma (WISH cells). According to their activities, the most potent flavonoids were 2´-nitroflavone (14), 2´,6-dinitroflavone (15) and the n-butyl ester of caffeic acid (29). When these derivatives were tested in the presence of recombinant human interferon-a2b (rhIFN-a2b), a cytokine exhibiting an antimitogenic action on WISH cells, an additive effect on cell growth inhibition was observed. Time course studies of the antiproliferative action exerted by the active flavone derivatives or the rhIFN-a2b suggested that these compounds induced cell death.