10000 times volume reduction for fluorescence correlation spectroscopy using nano-antennas

L. C. ESTRADA; P. F. ARAMENDIA; O. E. MARTINEZ

OPTICS EXPRESS

OPTICAL SOC AMER

Año: 2008 p. 20597 - 20603

1094-4087

We present an experimental and theoretical study of a new scheme for Near-Field Fluorescence Correlation Spectroscopy that, using the field enhancement by optical nanoantennas, allows the reduction of the observation volume 4 orders of magnitude below the diffraction limit. This reduction can be used in two different ways: to increase the sample concentration and to improve the spatial resolution of the dynamics under study. Our experimental results using individual gold nanoparticles and a 150μM Rose Bengal solution in glycerol confirm the volume reduction.