Campylobacter associated reactive arthrtis: a regional study in synovial liquid.

ABDÓN A; DI GENARO S; TAMASHIRO H; MATTANA C; LACIAR A

Merlo, San Luis

Congreso; XXII Reunión anual de la Sociedad de Biología de Cuyo; 2004

Sociedad de Biología de Cuyo

Reactive arthritis is an aseptic synovitis that can appear after primary Campylobacter infection. The immunological mechanisms of synovitis involve chronic inflammation by antigens deposited in the articulation and autoimmune response to articular components. The objective of the present study was to investigate Campylobacter antibodies in synovial liquids (SL) of patients with arthropathies from San Luis. Twenty SL from patients with rheumatoid arthritis (RA), 5 with spondyloarthropathies and 10 with arthrosis (negative controls) were studied. The antibody determination was done by ELISA, using as antigen Campylobacter cultures disrupted by sonication. The cutoff point was calculated as the mean + two standard deviations of the optical densities of negative controls. C. jejuni specific immunoglobulin response was detected in 3 SL of patients with RA, and C. jejuni specific IgA response was detected in 2 SL. According with the results we concluded that Campylobacter infection could be associated with arthropathies in San Luis.