INVESTIGADORES
DI GENARO Maria Silvia
congresos y reuniones científicas
Título:
Effect of Yersinia enterocolitica O:8 infection on glucose homeostasis
Autor/es:
VELAZQUEZ, M ; PELEGRINA M; DI GENARO MS
Lugar:
Mendoza
Reunión:
Conferencia; XL Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2022
Institución organizadora:
Sociedad de Biología de Cuyo
Resumen:
The relationship between metabolism and the immune response to bacterial infection on the organismal level remains to be completelyelucidated. Glucose is the key metabolite for immune cells and plays a critical role in the outcome of the infection. Here, we examined therelationship between sickness-induced anorexia and glycemia with cytokine production during the course of Yersinia enterocolitica (Ye)infection. C57BL/6 (WT) or TNFR1-deficient (TNFR1-/-) mice were orally infected with Ye O:8 by gavage. Body weight, food intake,glycemia and serum cytokine (TNF, IL-17) levels were evaluated during the course of infection. Both Ye-infected WT and TNFR1-/- miceexhibited significant weight loss (p
