INVESTIGADORES
DI GENARO Maria Silvia
artículos
Título:
Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenic Yersinia.
Autor/es:
HEIN J; SING A; DI GENARO MS; AUTENRIETH IB
Revista:
MICROBIAL PATHOGENESIS
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Manchester; Año: 2001 vol. 31 p. 195 - 199
ISSN:
0882-4010
Resumen:
Previous results have demonstrated an essential role of gamma interferon (IFN-gamma) in resistance against Yersinia enterocolitica. Hence, we investigated the course of Yersinia infection in mice deficient for the IFN-gamma-inducing cytokines interleukin-12 (IL-12 p40(-/-)) or interleukin-18 (IL-18(-/-)). The experiments described herein argue for a critical role of both cytokines in protective immune responses against this pathogen.
