INVESTIGADORES
DI GENARO Maria Silvia
artículos
Título:
PROTECTIVE INDUCED BY A YERSINIA ENTEROCOLITICA SEROVAR O:8 CELLULAR EXTRACT
Autor/es:
DI GENARO, M.S.; ESCUDERO M.E.; MACCIONI M.; S. DE GUZMÁN A.M
Revista:
BIOCELL
Editorial:
INST HISTOL EMBRIOL-CONICET
Referencias:
Lugar: Mendoza; Año: 1996 vol. 20 p. 235 - 241
ISSN:
0327-9545
Resumen:
The purpose of this study was to investigate the protective power of a cellular extract (CE) from Y. enterocolitica 0:8 grown in condition of expression of chromosomal antigens. Mice were immunized by s.c. route and challenged with: 0 LD50 (1 x 10(4) CFU/ml). Immunoblotting showed that CE-specific serum reacted with several CE antigens. Prominent bands, of molecular weights 60 and 35.5, were present in cytoplasmic and membrane fraction, respectively. The lipopolysaccharide (LPS) was detected in CE. These findings suggest that chromosomally-encoded antigens present in CE may induce protection against Y. enterocolitica infection. Both humoral and cellular immune response contribute to protection in mice.
