INVESTIGADORES
ROSSI juan pablo Francisco
artículos
Título:
Vanadate inhibition of active Ca2+-transport across human red cell membranes
Autor/es:
ROSSI P.J., Y REGA, A.F
Revista:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 1981 vol. 648 p. 145 - 150
ISSN:
0005-2736
Resumen:
(1) Vanadate (pentavalent vanadium) inhibits with high affinity (K0. s = 3 gM) the ATP-dependent Ca 2+ efflux in reconstituted ghosts from human red cells. (2) To inhibit Ca 2+ efflux vanadate has to have access to the inner surface of the cell membrane. (3) The inhibitory effect of vanadate is potentiated by intracellular Mg 2+ and by intracellular K +. (4) Ca 2+ in the external medium antagonizes the inhibitory effect of vanadate.
