Synthesis, polymorphism and insecticidal activity of methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-carboxylate against Anopheles arabiensis mosquito

VENUGOPALA, K; NAYAK, S; GLEISER, RM; SÁNCHEZ-BORZONE, M; GARCIA DA; BARTHI, O

CHEMICAL BIOLOGY & DRUG DESIGN

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2016 vol. 88 p. 88 - 96

1747-0277

Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector-borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In the present study pyrimido[2,1-b]quinazoline derivative DHPM3 has been synthesised by three steps chemical reaction and screened for larvicide, adulticide and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.