Synthesis and Evaluation of New Halogenated GR24 Analogs as Germination Promotors for Orobanche cumana

CHEN, YUCHAO; KUANG, YI; SHI, LIYANG; WANG, XING; FU, HAOYU; YANG, SHENGXIANG; SAMPIETRO, DIEGO A.; HUANG, LUQI; YUAN, YUAN

Frontiers in Plant Science

Frontiers Media S.A..

Lugar: Lausana; Año: 2021 vol. 12 p. 1 - 9

Orobanche and Striga are parasitic weeds extremely well adapted to the life cycle of their host plants. They cannot be eliminated by conventional weed control methods. Suicidal germination induced by strigolactones (SLs) analogs is an option to control these weeds. Here, we reported two new halogenated (+)-GR24 analogs, named 7-bromo-GR24 (7BrGR24) and 7-fluoro-GR24 (7FGR24), which were synthesized using commercially available materials following simple steps. Both compounds strongly promoted seed germination of Orobanche cumana. Their EC50 values of 2.3±0.28×10−8M (7BrGR24) and 0.97±0.29×10−8M (7FGR24) were 3- and 5-fold lower, respectively, than those of (+)-GR24 and rac-GR24 (EC50=5.1±1.32?5.3±1.44×10−8 ; p