Relative bioavailability and comparative clinical efficacy of different ivermectin oral formulations in lambs.

SUAREZ, G.; ALVAREZ, L., CASTELLS, D.; CORREA, O.; FAGIOLINO, P.; LANUSSE, C.

BMC VETERINARY RESEARCH

BIOMED CENTRAL LTD

Lugar: Londres; Año: 2013 p. 21 - 28

1746-6148

Several oral ivermectin (IVM) formulations for use in sheep are available in the pharmaceutical veterinary market in different countries. All of them are indicated at the same dose rate to treat the gastrointestinal nematodes. However, there is a lack of information on the relative systemic exposure (plasma bioavailability) and clinical efficacy among oral formulations routinely used in sheep. The main goal of the work reported here was to perform a pharmaco-parasitological assessment of three different IVM oral formulations in lambs infected with multiple resistant gastrointestinal nematodes.The comparative drug systemic exposure (IVM plasma concentrations) and nematodicidal efficacies (clinical efficacy) in lambs were determined for a reference (RF) and two different test (T1, T2) IVM oral formulations. One hundred and fifty six (n= 156) healthy Corriedale lambs, naturally infected with multiple resistant gastrointestinal nematodes were allocated into four experimental groups (n=39). Animals in each group received treatment (200 µg/kg) with either the RF, one of the test IVM formulations or were kept as untreated control.Blood samples were collected over 15 days post-treatment.