INVESTIGADORES
GONZALEZ Alejandro Hernan
artículos
Título:
Pulsatile Zone MPC with asymmetric stationary cost for artificial pancreas based on a non-standard IOB constraint
Autor/es:
ABUIN, PABLO; FERRAMOSCA, ANTONIO; TOFFANIN, CHIARA; MAGNI, LALO; GONZÁLEZ, ALEJANDRO HERNÁN
Revista:
JOURNAL OF PROCESS CONTROL
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2024
ISSN:
0959-1524
Resumen:
This paper presents a novel pulsatile Zone Model Predictive Control (pZMPC) for glycemic control in type1 diabetic patients, which is an extension of the one presented in literature. Its main characteristics are (i) theexplicit inclusion of a time-varying insulin on board constraint to promote a non-zero insulin delivery after astandard bolus infusion and to increase the postprandial system controllability, and (ii) the softening of thisconstraint to ensure closed-loop stability for an enlarged domain of attraction. Additionally, configurationmethods are proposed for the insulin on board constraint based on carb counting regression models andglycemia rate of change information. In-silico results in the FDA-approved UVA/Padova simulator, underover/underestimation of the meal amounts, and under insulin sensitivity variability, show a superiority ofthe proposed glucose control over postprandial periods.
