Antioxidant activity of atrial natriuretic peptide (ANP) in the exocrine pancreas

COURREGES, ANA PAULA; ALVAREZ, GUADALUPE INÉS; OCHOA, FEDERICO; ZOTTA, ELSA; REPETTO, MARISA; VATTA, MARCELO; BIANCIOTTI, LILIANA

Mar del Plata

Congreso; LXVIII Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2022

Sociedad Argentina de Investigación Clínica (SAIC)

ANTIOXIDANT ACTIVITY OF ATRIAL NATRIURETI PEPTIDE (ANP) IN THE EXOCRINE PANCREASCourreges, Ana P, Alvarez Guadalupe I, Ochoa Federico, Lairion Fabiana, Zotta Elsa, Repetto Marisa, Vatta Marcelo S , Bianciotti Liliana G. We previously reported that ANP is produced by the exocrine pancreas and that it plays a beneficial role in the outcome of acute pancreatitis (AP). It reduces trypsinogen activation and the inflammatory response and restores glutathione depletion. In the present study we assessed different parameters of oxidative stress and antioxidant defenses in Sprague Dawley rats with AP induced by four repetitive cerulein injections (40μg/Kg). Thirty minutes before the first cerulein injection animals were infused with either saline (control) or ANP (1μg/Kg/h) for 60 min. Following euthanasia (60 min after the last cerulein injection) pancreatic samples were harvested. ANOVA followed by a Student Newman Keuls was used for statistical analysis. Results are expressed as the mean±SD and p