INVESTIGADORES
ABRAHAM gustavo Abel
congresos y reuniones científicas
Título:
Osteogenic effect of composite nanofibrous scaffolds with osteostatin
Autor/es:
E. GONZÁLEZ MELLIAN; I.N. CAMAL RUGGIERI; F. SPERONI; O. SANTIAGO; M. STUR; S.J. RENOU; D. OLMEDO; G. RIVERO; G.A. ABRAHAM; S. FELDMAN
Lugar:
Mar del Plata
Reunión:
Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials (COLAOB 2023); 2023
Institución organizadora:
INTEMA (UNMdP-CONICET)
Resumen:
Composite electrospun nanofiber matrices have emerged as promising scaffolds for bone tissue engineering. These matrices offer several advantages, including providing structural support and mimicking the intricate architecture of native tissue, which facilitates cellular growth and tissue regeneration. This study aims to investigate the biocompatibility and osteogenicity in vivo of electrospun nanofibrous scaffolds based on poly(ε-caprolactone) (PCL) and hydroxyapatite (nHAp) nanoparticles with and without the surface immobilization of osteostatin (S-O and S). Osteostatin, a pentapeptide 107-111 of the parathyroid hormone (PTHrP 107-111), was used to increase the healing potential of composite scaffolds.
