Core-shell electrospun nanofibers based on Soy Protein Isolate for tissue engineering applications

M. POPOV; G.A. ABRAHAM

Mar del Plata

Congreso; XII Latin-American Congress of Artificial Organs and Biomaterials (COLAOB 2023); 2023

INTEMA (UNMdP-CONICET)

The properties combination from two polymeric phases enabled by coaxial electrospinning have drawn significant attention in the tissue engineering. The core-shell structure proves instrumental in leveraging distinct polymeric phases to their fullest potential. Among the various strategic combinations, researchers have employed this structure to integrate mechanically robust polymers in the core, while utilizing more biocompatible polymers for the shell. This dual approach enhances both the mechanical resilience and biocompatibility of the resultant fibers. Electrospun soy protein isolate (SPI) is being studied to be applied in the tissue engineering field, but the obtained mats lack of optimal mechanical properties, being highly brittle. Therefore, the aim of this work is to obtain core-shell fibers using the coaxial electrospinning technique using PCL, an FDA approved polymer, and SPI as core and shell phases, respectively, and conduct morphological and physicochemical characterizations