Nanocomposites with Magnetic Response for the sustained release of Model Proteins

JIMENA SOLEDAD GONZALEZ; VERONICA LASSALLE; VERA ALEJANDRA ALVAREZ

Bahía Blanca

Simposio; IX Simposio Argentino de Polímeros (SAP2011); 2011

Stimuli-sensitive polymers are materials that respondto temperature, light, pH, ionic strength or electric andmagnetic fields, producing a desired effect such as adiscontinuous change in optical or mechanical behavior,surface properties, or in volume or shape (Liu et. al.,2009). A way to obtain these devices is to dispersenanostructures in a polymer gel to form ananocomposite hydrogel. In general terms,nanocomposite hydrogels may be defined as crosslinkedpolymer networks, modified with nanoparticles (NPs),swollen with water or biological fluids. Nanoparticlesadd unique physical properties to polymer hydrogels forelectronics, optics, drug delivery, and other biotechnologicalapplications (Schexnailder et. al, 2009).Controlled drug release provides advantages overconventional routes of drugs administration such asmajor delivery efficiency and site-specific therapy. Ithas been demonstrated that PVA-coated superparamagneticiron oxide NPs can serve as delivery system fordrug targeting in synovial membrane tissue, as they aretaken up intracellularly both, in vitro and in vivo(Hatakeyema et. al., 2009). Ferrogels with different NPssizes showed different release rates even though theypossessed the same concentration of nanomagnets.The aim of this work was to obtain, characterize andapply ferrogels in adsorption and controlled release ofproteins. For this purpose, ferrogels composed of PVAand magnetite (iron oxide: Fe3O4) NPs of differentcharacteristics and sizes were synthesized by twodifferent routes: i.by “in-situ” precipitation of ironoxides and;ii. by adding NPs coated by chitosan (CS).The obtained biomaterials were tested for the adsorptionof bovine serum albumin (BSA), which was selected asmodel protein.