Layered double hydroxide applications in biomedical implants

ROJAS, RICARDO; MOSCONI, GIULIANA; ZANIN, JUAN PABLO; GIL, GERMAN A.

APPLIED CLAY SCIENCE

ELSEVIER SCIENCE BV

Año: 2022 vol. 224

0169-1317

Biomedical implants are powerful tools for replacing, repairing, and reconstructing damaged tissues and organs.A wide range of materials are used for these devices, and the application of nanotechnology has allowedremarkable achievements in regenerative medicine. Layered double hydroxides (LDH) incorporation to thesematerials is increasingly studied due to their 2D morphology, biocompatibility, drug storage and release capabilityas well as cell adhesion, proliferation, and differentiation capacity. Nevertheless, due to its incipientdevelopment, there is still no systematic and comprehensive description of the state of the art. Here we providean overview of the materials, preparation methods, properties, and applications of LDH-based biomedical implants.The customization capacity of LDH and their inherent properties, such as biocompatibility, morphology,anion exchange and cell internalization capacity allow their use in a wide range of applications. Nevertheless, acareful selection of the materials with which they combine and the strategy to produce this combination isessential to produce an optimization of the obtained functionality. The potential of LDH as components ofbiomedical implants is great, but systematic research is still necessary, especially in their interaction with cellsand tissues, to transform this potential in real applications.